患者信息： 女 47歲
因為high Her2表現, 醫生告知一clinic tryal by NSABP AC taxol and or
Herceptin bundled with radiation(owing to BCT case)and taximofin as:
A randomized trial comparing the safety and efficacy of adriamycin and clophosphamide fllowedby taxol(AC大於T)
to that of adriamycin and cyclophosphamide
followed by taxol plus herceptin (AC小於T
H) in node-positive breast cancer patients
who have tumors that overexpress her2 (NSABP
b-31) version 5/16/03
About 2700 women will take part in this study.
Have to test in the followgin to be eligible.
* physical examination
* pelvic examination (if you have uterus)
* blood test
* chest x-ray
* bone scan (optional)
* MUGA scan (for heart functions test)
* eletrocardiogram (EKG)
Need to take all tests, many times x-ray,
antibiotic, and antiallergic drugs like
dexmethasone, diphenhydramine; and either
cimetidine,ranitidine, or famotidine.
Becaused of the nature of randomization, only
have 1/2 chance to get Herceptin. And,
can not take femara instead of
taximofin. 3/4 chance to get rid of recurrence
possibility against 1/5 permanent heart damage.
If being done nothing, only have 1/2 chance
to avoid recurrence.