患者信息: 47歲

  • 2.5月
    2003年7月底發現乳房內上硬塊
    經x光超音波切片診斷為
    乳癌
    本人47歲, 經加州醫生診斷為乳癌第二期,1.5公分
    2/6 前哨淋巴有癌細胞, 分化不良
    Fish檢驗Her2/neu 2.47陽性
    雌激素100%陽性, 異黃酮體-5%陰性
    已保留手術且取出6顆淋巴, 尚未停經
    因為high Her2表現, 醫生告知一clinic
    tryal by NSABP AC taxol and or
    Herceptin bundled with radiation
    (owing to BCT case)and taximofin as:
    A randomized trial comparing the safety
    and efficacy of adriamycin and
    cyclophosphamide fllowedby taxol(AC大於T)
    to that of adriamycin and cyclophosphamide
    followed by taxol plus herceptin (AC小於T
    H) in node-positive breast cancer patients
    who have tumors that overexpress her2 (NSABP
    b-31) version 5/16/03

    About 2700 women will take part in this study.
    Have to test in the followgin to be eligible.
    * physical examination
    * pelvic examination (if you have uterus)
    * mammogram
    * blood test
    * chest x-ray
    * bone scan (optional)
    * MUGA scan (for heart functions test)
    * eletrocardiogram (EKG)
    Need to take all tests, many times x-ray,
    antibiotic, and antiallergic drugs like
    dexmethasone, diphenhydramine; and either
    cimetidine,ranitidine, or famotidine.
    Becaused of the nature of randomization, only
    have 1/2 chance to get Herceptin. And,
    can not take femara instead of
    taximofin. 3/4 chance to get rid of recurrence
    possibility against 1/5 permanent heart damage.
    If being done nothing, only have 1/2 chance
    to avoid recurrence.

    敬請賜教是否值得甘冒損失自愈機能冒險一試
    謝謝
    ==============
    請教醫生:
    本人47歲, 經加州醫生診斷為乳癌第二期,1.5公分
    2/6 前哨淋巴有癌細胞, 分化不良
    Fish檢驗Her2/neu 2.47陽性
    雌激素100%陽性, 黃體素-5%陰性
    已保留手術且取出6顆淋巴, 尚未停經因為high Her2表現, 醫生的治療方向為:
    AC (240mg) 4 dozage
    Taxol (4 dozage) and/or Herceptin (1 yr)
    Tamoxifin 5 years

    請問未治療與治療存活率差多少
    是否七成淋巴轉移陽性病患用剋癌勝(Taxol)效果有限?Famera副作用是否較少, 只適用停經婦女嗎?
    如因化療停經算是停經婦女嗎?

    謝謝!

    2003-11-02 04:10:14

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